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Typically, patients experience immediate improvements in hydration and energy levels, which can last for several days to a week
The unknown rate constants for R 1 , R 2 , R 3 , R 4 and R 5 for the respective models were fitted using the LSQNONLIN function in MATLAB, a non-linear least squares solver
1012 Compared to peptides, small-molecule compounds are easier to develop into oral preparations and improve patient compliance
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